From Southern California take Hwy 14 to 395 through Indepence and Lone Pine all the way up to Lee Vining. Mono Lake is to your right
Don't use bodyspray or cologne when going to Mono. The bugs there like it more than anyone you might encounter.
Leaving the high desert we headed up highway 395 to Mono Lake and made it just around sunset. We managed to get in afternoon shooting some milky way night time shots and stuck around and waited for this awesome sunrise over Mono before heading back home to the high desert.All in a days work.